I frequently stay in the Holiday Inn Express Oxford Road for business purposes and generally find it fine for the purpose, plus the breakfast is no-frills but cheering and adequate.
learned from recent experience though that if you're allocated a room on the Oxford Road site on a weekend night, it can be very noisy as it backs onto a row of nightclubs which keep the party going at full volume until about 3.30 a.m.
I did mention this when I checked out and was told that there should have been earplugs available in the room. But on future occasions, I've learned to take no chances - have earplugs with me and request a room on the Hulme Road side only next time. [Less]