When my family and visit San Francisco, we love staying at the Holiday Inn Fisherman's Wharf. We are no tourists, but it is central to everything we love doing... we love the walk through Columbus
Ave to Chinatown to Union Square. Everything is a short Uber ride away, if you get tired of the walk. If you want to do the touristy things, it is blocks away from the famous Buena Vista for your Irish Coffee needs, across the way from Fisherman's Wharf and Pier 39, the Exploratorium, the Port of SF, Ghirardelli Square, and access to the Famous Cable Cars.
The staff is amazing. So friendly and helpful! [Less]