Brownsville - S Padre Island Int'l Arpt (BRO) : Take 77 South and exit on 100. Take 100 until you get to South Padre Island. Once you cross the causeway you will turn right on Padre Blvd. Go North until you see the Holiday Inn Express.
Valley International Airport - Harlingen (HRL) : Turn left onto Les Mauldin Road, turn right onto South Iowa Avenue, turn right onto Boca Chica Blvd, turn left onto Minnosota Ave. Follow 48 onto 100, turn right to Port Isabel cross causeway and turn north on South Padre Blvd.
McAllen Miller International Airport (MFE) : From Brownsville South Padre Island International Airport take N Minnesota Ave to TX 48 E/E 14th Street. Continue on TX 48 E to South Padre Island. Turn left onto Padre Blvd State Park Road 100. You will arrive at 6502 Padre Blvd.