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The Duomo is an artistic monument and a privileged place of prayer. The Cathedral is strongly linked to memory and to the Magisterium of the Bishops who have succeeded to the Throne of St. Ambrose. The Gothic cathedral took nearly six centuries to complete. It is the largest church in Italy (the larger St. Peter's Basilica is in the State of Vatican City) and the fifth largest in the world.

The theatre was inaugurated on 3 August 1778. Most of Italy's greatest operatic artists, and many of the finest singers from around the world, have appeared at La Scala during the past 200 years. The theatre is regarded as one of the leading opera and ballet theatres in the world.

It was built in the 15th century by Francesco Sforza, Duke of Milan, on the remains of a 14th-century fortification. Later renovated and enlarged, in the 16th and 17th centuries it was one of the largest citadels in Europe. Extensively rebuilt by Luca Beltrami in 1891–1905, it now houses several of the city's museums and art collections.

The Galleria Vittorio Emanuele II is one of the world's oldest shopping malls. Housed within a four-story double arcade in central Milan the Galleria is named after Victor Emmanuel II, the first king of the Kingdom of Italy. It was designed in 1861 and built by architect Giuseppe Mengoni between 1865 and 1877.

The district is bordered by four main thoroughfares - Via Monte Napoleone, Via Alessandro Manzoni, Via della Spiga and Corso Venezia - hence the Quadrilatero reference. The Quadrilatero della moda, is a high-class shopping district in the centre of the Italian city of Milan, characterised by the presence of numerous boutiques and related retail outlets which represent most of the world’s major fashion houses.

The Last Supper is a late 15th-century mural painting by Leonardo da Vinci in the refectory of the Convent of Santa Maria delle Grazie, Milan. It is one of the world's most famous paintings.