Holiday Inn Santee

Just off I‑95 in Santee, South Carolina, the Holiday Inn Santee offers a relaxing stay near the shores of Lake Marion, one of the largest lakes in the state. Surrounded by peaceful Lowcountry scenery, our location provides easy access while still feeling removed from the rush of everyday travel.

Lake Marion is a major draw for anglers, famous for striped bass, crappie, bream, and some of the biggest catfish in the Southeast. Guests are also close to Santee State Park for boating and hiking, Edisto Memorial Gardens for seasonal blooms and butterflies, and several well‑known golf courses. Columbia and historic Charleston are both within driving distance for sightseeing, dining, and cultural attractions.

After a day on the lake or at meetings, enjoy amenities designed for comfort and convenience, including free Wi‑Fi, a 24‑hour Business Center, an indoor heated pool, and an on‑site restaurant serving comforting favorites. Warm Southern hospitality and a convenient location make every stay easy, productive, and enjoyable.