Holiday Inn Santee

Located just off I-95, in the heart of Santee, Holiday Inn Santee offers convenient access to one of South Carolina’s favorite recreation destinations. Surrounded by championship golf courses and the natural beauty of Lake Marion, our hotel is an ideal stop for road trippers, outdoor enthusiasts, and travelers seeking a relaxing getaway between Charleston and Columbia.

Spend your days casting a line on Lake Marion, exploring the trails and scenic views of Santee State Park, or teeing off at nearby courses like Santee National Golf Club and Santee Cooper Country Club. Whether you're planning a fishing trip, golf weekend, family vacation, or overnight stop along I-95, Santee offers easy access to some of the region’s most popular outdoor attractions.

After a day of adventure, unwind with thoughtful amenities designed for comfort and convenience. Enjoy a made-to-order meal at Kem's Restaurant & Bar, take a swim in the only indoor heated pool in Santee, stay connected with complimentary Wi-Fi, and relax in our pet-friendly accommodations. With flexible meeting space, a fitness center, and easy interstate access, Holiday Inn Santee makes every stay simple and enjoyable.