Holiday Inn Santee

Welcome to Holiday Inn Santee, where Southern hospitality meets modern comfort just off I-95 at Exit 98. Tucked between Charleston and Columbia in the heart of Santee, SC, our newly renovated, full-service hotel is your home base for lake days, family weekends, and everything in between. Same name, whole new energy.

Step outside and you're minutes from Lake Marion, one of South Carolina's largest freshwater lakes and a legendary fishing destination. Cast a line for largemouth bass, striped bass, and trophy catfish, or launch your boat and explore 110,000 acres of open water. Santee State Park is right down the road with hiking, kayaking, and pontoon tours through the flooded cypress forest. Prefer the links? Santee National Golf Club and Santee Cooper Country Club are just a short drive away.

When it's time to gather, we've got the space for it. Our 5,000 square feet of flexible event space is designed to flex, wedding festivities, family reunions, business meetings, or a weekend get together with the whole crew. From breakout sessions to rehearsal dinners, we make it easy to bring people together.

After a day on the lake or in meetings, reset and unwind. Grab a meal at Kem's Restaurant & Bar, take a swim in the only indoor heated pool in Santee, or settle into your fully renovated guest room. With complimentary Wi-Fi, a fitness center, pet-friendly accommodations, and easy interstate access, Holiday Inn Santee makes every stay feel effortless.