Roanoke Regional Airport (ROA) : Left on Hwy 419 to I 81 N to exit 143- Take exit 3E(Hersheburger Rd). Follow signs to airport
I 81South to exit 141 Turn Right onto 419 or Electric Rd Then right at Sheration Drive Then left onto Russell Drive Holiday Inn Express and Suites on the right.
I 77 North to I 81 North take exit 141. Turn left at light hotel is on right.
I 64 West to I 81 South take exit 141. Turn right at light is on right.
I 64 East to I 81 South take exit 141. Turn right at light is on right.