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Holiday Inn Express & Suites Buffalo Downtown - Medical CTR

601 Main Street , Buffalo, New York 14203

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Have a
EXPRESS Start™ Breakfast

It’s fresh, it’s hot, and it’s free. Dig into our free Express Start Breakfast full of your favorites to help kick start your day.

Breakfast offering may vary by hotel location

We’re big on the little things. Like Wi-Fi, coffee and tea, and all the in-room conveniences that make you feel right at home, even when you’re away.
Power up while you power down. Bedside outlets, a plush duvet, your pick of pillows, and a quiet place to settle in means you’ll get some solid shut-eye.

Explore Our Hotel

We welcome you to stay at our Holiday Inn Express & Suites Buffalo, located in the heart of downtown near Roswell Park, John R. Oishei Children's Hospital, Buffalo General Hospital, Convention Center and Canalside. Hotel parking is available nearby at additional charge in parking garage.

Enjoy being nestled in the heart of the Theatre District, where you can experience a grand performance at Shea's Performing Arts Center or the Irish Classical Theatre. Take in a concert at the Town Ballroom or TRALF located within the same block or hop on the above ground trolley train to the Key Bank Center. The Seneca Buffalo Creek Casino offers a free shuttle to and from the casino. Explore & More - Ralph C. Wilson Jr. Children's Museum and the Naval Park are also just a few blocks away.

The city is also packed with events and festivals at Canalside and Sahlen's Field. Admire contemporary art at the Albright-Knox Art Gallery or discover Frank Lloyd Wright's stunning residencies nearby and marvel at the Darwin Martin House.

Don't forget to make the 20 mile trip to one of the Nation's North American Wonders of the World - Niagara Falls!For those traveling on business we are in close proximity to M&T Bank, Buffalo Niagara Medical Campus, and New Era Cap. You will appreciate our 24-hour business center and fitness center. Also located adjacent to the hotel is a TGI Friday’s restaurant.

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Room+ -
Guest Rooms
Guest Rooms
All rooms are suites with a king bed in the bedroom area and a pullout couch in a separate livingroom. There is a door that closes between the two rooms. Also in livingroom is a lounge chair and desk. All rooms have two 49" tvs, microwave, mini fridge and Keurig Maker.
Room Features


  • Black-out Shades
  • Iron/Ironing Board
  • In-room Safe
  • Separate Hanging Closet
  • In-Room Heating and A/C Controls
  • Sofa Bed/Sleeper Couch

Bathroom/Personal Care

  • Private Bathroom
  • Bathroom Amenities Available
  • Hair Dryer

In-Room Features

  • Mini Refrigerator
  • Microwave
  • Coffee Maker
  • Tea Maker
  • Work Desk with Lamp
  • Desk-level Electrical Outlet
  • Cable/Satellite
  • Premium Channels
  • Direct-dial Phone
  • Phone with Voicemail

Added Value

  • Connecting Rooms Available
  • Separate Living Room
  • Complimentary Coffee/Tea Supplies
Eat & Drink+ -
Eat & Drink
A TGI Friday's restaurant adjacent to the hotel. Serves lunch and dinner. Family oriented with a seperate bar area.
  • Full Breakfast Included
  • Breakfast Buffet Included
  • Continental Breakfast Included

Hotel Restaurants

TGI Friday's

We have a TGI Friday's attached to our hotel which is open Sunday through Thursday 11 am to 12 am and Friday and Saturday open 11am to 1am.

Location: TGI Friday's

Serves: Lunch, Dinner, Dessert

Hours of Operation: : 11:00 AM-11:00 PM

Connect+ -

Business Services

  • 0 Meeting Room(s) Available
  • On-Site Business Center

Internet Access

  • Free High-Speed Internet in all Rooms
  • Wireless Internet service is free for all IHG® One Rewards members
More+ -

Entertainment & Recreation


Health & Fitness

Complimentary Fitness Center

Fitness Center located on lobby level. equipped with 2 treadmills, 1 elyptical machine and 1 recumbant bike. Free weights, stretch bands and mats and boci ball also in fitness center.

Hours of Operation: 5:00 AM to 5:00 AM

Fitness Center Type: LIMITED

Fitness Center Equipment:

  • Elliptical Machines
  • Free Weights
  • Stationary Bicycle
  • Treadmill

Last Renovation of Fitness Center Equipment: 2017

Housekeeping & Laundry

  • Daily Housekeeping
  • On-site Guest Self-Laundry Facilities
  • Hours of Operation: 6:00 AM - 11:00 PM

Added Value

  • Wake Up Calls
  • Ice Machine

Hotel Details

601 Main Street

Buffalo, New York 14203

United States


Check In: 3:00 PM

Check Out: 11:00 AM

Check-in Age: 21

  • Parking + -

    • Hotel recommends parking at a city owned garage 1.5 blocks from the hotel. Payment made directly to garage. Fee $9-14. No onsite parking except for temporary spots for the check in / check out process. Hotel offers FREE shuttle to and from garage.
  • Shuttle + -

  • Accessibility + -

      Accessible Hotel Areas

    • Public Entrance
    • Guest Rooms
    • Elevators
    • Public Restrooms
    • Registration Desk
    • Exercise Facility
    • Business Center

      Hotel Areas with Accessible Routes from Accessible Public Entrance

    • Registration Area
    • Accessible Guest Rooms
    • Business Center
    • Meeting Room
    • Exercise Facility

      Provided by Hotel

    • Accessible Self Parking
    • Van Accessible Self Parking
    • Ramp Access
    • Portable Bathtub Seats
    • Closed Caption TVs
    • Telephone with TDD
    • Visual Alarm/Alert in Guest Rooms
    • Visual Alarm/Alert in Public Spaces
    • Communication Kits with Visual Alarms
  • Pet Policy + -

    • Service Animals Allowed
    • Pet Deposit per Stay: 0 USD
    • Pet Fee per Night: 0 USD
    • No Pets Allowed. Service animals are welcome. Please contact front desk about additional details on service animal policies.
  • Facility + -

    • Smoke-Free Facility
    • Number of Floors: 7
    • Total Number of Rooms: 146
    • Number of Suites: 146
    • Number of Non-Smoking Rooms: 146
    • Number of Accessible Rooms: 7
    • Connecting Rooms Available
    • Public Spaces Renovated in: 2017
    • Guest Rooms Renovated in: 2019

     Print Fact Sheet

  • Credit Cards + -

    • American Express
    • Visa
    • MasterCard
    • Diners Club
    • Carte Blanche
    • JCB
    • Discover
  • Be The Readiest® for your stay

    Our Highlights
    Highlights subtitle
    TGI Friday's Is in the building!
    Gateway to Canada!
    Free Trolley Train to Canalside - Waterfront
    Heart of the Theatre District and Entertainment
    Medical Campus just blocks away!
    TGI Friday's Is in the building!
    Restaurant is located off the lobby level of the hotel in the same building. American Fare food and drinks to enjoy at the convenience of a few steps off the elevator!
    Gateway to Canada!
    Just a short drive from our hotel is the Peace Bridge, connecting the USA to Canada's Border.
    Free Trolley Train to Canalside - Waterfront
    Right outside our hotel is an above ground trolley train. It runs every 12-15 minutes and is free heading downtown. It goes to and from the Canalside area, Key Bank Center (Concerts, Bandits, Sabres), Harborcenter, Sahlen Field (Buffalo Bisons), Buffalo Naval Park and the Ralph Wilson Jr. Explore & More Children's Museum.
    Heart of the Theatre District and Entertainment
    We are located in the same block as Shea's Performing Arts Center, Irish Classical Theatre, Alleyway Theatre and music venues Tralf and Town Ballroom. Within 3 blocks are 50 restaurants and bars.
    Medical Campus just blocks away!
    Our hotel is situated within 4 blocks of Roswell Park Comprehensive Cancer Center, John R. Oshei Children's Hospital, Buffalo General Hospital, Jacob's School of Medicine and Buffalo Hearing & Speech Center.
    Green Engage
    All of our hotels use the IHG Green Engage system, an innovative online environmental sustainability system that gives our hotels the means to measure and manage their impact on the environment. It’s our way of making sure we’re protecting our surroundings for our guests today, and tomorrow.

    FAQs for Holiday Inn Express & Suites Buffalo Downtown - Medical CTR

    • Yes, when you book your stay at Holiday Inn Express & Suites Buffalo Downtown - Medical CTR direct with IHG, choose one of our flexible rates which include the flexibility to change or cancel your reservation at no charge. For full details, refer to our Travel Advisory details.

    • No, there is not a local area shuttle available at Holiday Inn Express & Suites Buffalo Downtown - Medical CTR.

    • No, Holiday Inn Express & Suites Buffalo Downtown - Medical CTR does not have a pool.

    • Breakfast at Holiday Inn Express & Suites Buffalo Downtown - Medical CTR is available from 6:00 AM to 10:00 AM.

    • Check-in at Holiday Inn Express & Suites Buffalo Downtown - Medical CTR is from 3:00 PM, and check-out time is 11:00 AM. Contact the hotel directly for options available for early check-in or late check-out.

    • Yes, the Holiday Inn Express & Suites Buffalo Downtown - Medical CTR offers free WiFi!

    • Holiday Inn Express & Suites Buffalo Downtown - Medical CTR has 1 restaurant. TGI Friday's.

    • Yes, there is an onsite fitness center at Holiday Inn Express & Suites Buffalo Downtown - Medical CTR.

    • Rates for accommodations at Holiday Inn Express & Suites Buffalo Downtown - Medical CTR vary by season. For your rate options, please input your dates.

    • The Holiday Inn Express & Suites Buffalo Downtown - Medical CTR has 146 guest rooms. Enter your dates to view available rooms for your stay.

    • No, pets are not allowed at Holiday Inn Express & Suites Buffalo Downtown - Medical CTR.