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Holiday Inn Express & Suites St. Louis South - I-55

4250 Midamerica Lane, St. Louis, MO 63129 United States

Check-In:   3:00 PM

Check-Out:   11:00 AM

Minimum Check-In Age:   21


Front Desk:   1-314-8940700

Amenities & Services

Free breakfast
Free breakfast
Service animals only
Service animals only
Fitness center
Fitness center
Wifi included
Wifi included
Meeting facilities
Meeting facilities


Modern hotel near downtown St. Louis sights

Welcome to the new Holiday Inn Express & Suites St. Louis South I-55!

South St. Louis's newest and most modern Holiday Inn Express Hotel nestled within a growing development at the intersection of Butler Hill Road & I-55 just one mile south of I-270/255 with access to everything St. Louis has to offer. The hotel is just 14 miles directly south of Downtown St. Louis and located at exit #195 from I-55.

Business travelers will benefit from our central location with easy on/off access to I-55 that offers access to the different areas of St. Louis within minutes. The hotel complex includes the Barnes-Jewish Siteman Cancer Center & Mercy Health. We are just minutes from Metlife, Anhueser Busch, Cigna and the National Cemetary Association.

Our non smoking Holiday Inn Express & Suites St. Louis I-55 hotel is very convenient to guests visiting Busch Stadium, Gateway Arch, Grant's Farm, Magic House, St. Louis Science Center, St. Louis Zoo, Forest Park, River City Casino and much more!

Hotel Guests can enjoy an array of amenities including guest room suites, Indoor Pool, Suite Shop, Two Meeting Rooms, Complimentary Express Start Breakfast, Complimentary High Speed Wired & Wireless Internet, Comfortable Great Room with Outdoor Patio and warm Cookies & Milk served nightly.

Guests will enjoy our midwest hospitality in South St. Louis. Our goal is to make every guest feel at home so that we exceed all of their expectations!

Ihg hotel


Enjoy this new & modern guest room designed for today's business and leisure traveler. Features a 49 inch HD TV, media charging station, fridge, microwave, Keurig brewer, work desk with ergonomic chair, in-room safe, triple sheeted bedding & enhanced bath experience with curved shower rod.

Experience St. Louis

Explore Downtown St. Louis and the new Arch Grounds that are being updated to connect the downtown area to the riverfront. This project will transform the most iconic structure in St. Louis and provide easy walking access. For the daring River City Casino has opened just a few miles north of the hotel and recently updated several food outlets & bars.

FAQs for Holiday Inn Express & Suites St. Louis South - I-55

Yes, when you book your stay at St. Louis South - I-55 direct with IHG, choose one of our flexible rates which include the flexibility to change or cancel your reservation at no charge. For full details, refer to our Travel Advisory details.
No, there is no on site restaurant at St. Louis South - I-55.
Breakfast at St. Louis South - I-55 is available from 6:00 AM to 10:00 AM.
Check-in at St. Louis South - I-55 is from 3:00 PM, and check-out time is 11:00 AM. Contact the hotel directly for options available for early check-in or late check-out.
Yes, St. Louis South - I-55 has an indoor pool.
Yes, there is an onsite fitness center at St. Louis South - I-55.
Read more FAQs



EXPRESS Start™ Breakfast

It’s fresh, it’s hot, and it’s free. Dig into our free Express Start Breakfast full of your favorites to help kick start your day.

Breakfast offering may vary by hotel location



We’re big on the little things. Like Wi-Fi, coffee and tea, and all the in-room conveniences that make you feel right at home, even when you’re away.



Power up while you power down. Bedside outlets, a plush duvet, your pick of pillows, and a quiet place to settle in means you’ll get some solid shut-eye.

Green Engage Image

All of our hotels use the IHG Green Engage system, an innovative online environmental sustainability system that gives our hotels the means to measure and manage their impact on the environment. It’s our way of making sure we’re protecting our surroundings for our guests today, and tomorrow.