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Holiday Inn Express Durham

2516 Guess Road, Durham, NC 27705 United States

Check-In:   3:00 PM

Check-Out:   12:00 PM

Minimum Check-In Age:   21


Front Desk:   1-919-3133244

Reservation:   1-888-Holiday

Amenities & Services

Free breakfast
Free breakfast
Pets allowed
Pets allowed
Fitness center
Fitness center
Wifi included
Wifi included


Durham, NC hotel with Medical Center shuttle

Durham, NC Hotel Near Duke University Medical Center

With an ideal location along I-85 and the Durham Freeway, and a free shuttle service to Duke University Medical Center, Duke University Hospital, and area medical facilities, the Holiday Inn Express® Durham hotel offers clean, newly renovated guest rooms, comfort and convenience for your next trip. We pride ourselves on being a Home Away From Home for our guests by offering great service at an affordable price.

Our hotel near Duke University is just minutes from Treyburn Corporate Park and has everything you need for a productive stay in Durham, NC. Use the complimentary Wi-Fi access or our business center to keep in touch with home and the office.

Our hotel is also ideal for visiting NC Central, NC School of Science and Math, and UNC Chapel Hill. There are a number of attractions to see on Duke University campus, including Duke Chapel, Nasher Museum of Art and Sarah P Duke Gardens. In town, catch a Durham Bulls game or see a show at Durham Performing Arts Center. The North Carolina Museum of Life and Science is a place where children have fun learning, and our hotel near Eno River State Park is ideal for hikers and paddlers alike.

You are sure to feel at home in our clean, comfortable and newly renovated accommodations. Enjoy a free, hot breakfast buffet, sparkling outdoor pool and our new Fitness Center. Call today, and let our Durham hotel exceed your expectations!

Ihg hotel

Guest rooms & suites

You're sure to feel right at home when you stay in one of the NEWLY RENOVATED guest rooms. Enjoy modern amenities like free Wi-Fi access and a 37-inch flat screen TV. You can make and store snacks with a microwave and fridge. Each room also has an executive desk and triple-sheeted bedding.


Experience Durham

There's always something new at the Durham Performing Arts Center. This state-of-the-art, 2,800-seat theater hosts major concerts, comedians and plays. Past performances include the Nutcracker, Disney's The Lion King and Blue Man Group.

FAQs for Holiday Inn Express Durham

Yes, when you book your stay at Durham direct with IHG, choose one of our flexible rates which include the flexibility to change or cancel your reservation at no charge. For full details, refer to our Travel Advisory details.
No, there is no on site restaurant at Durham.
Breakfast at Durham is available from 6:00 AM to 10:00 AM.
Check-in at Durham is from 3:00 PM, and check-out time is 12:00 PM. Contact the hotel directly for options available for early check-in or late check-out.
Yes, Durham has an outdoor pool.
Yes, there is an onsite fitness center at Durham.
Read more FAQs



EXPRESS Start™ Breakfast

It’s fresh, it’s hot, and it’s free. Dig into our free Express Start Breakfast full of your favorites to help kick start your day.

Breakfast offering may vary by hotel location



We’re big on the little things. Like Wi-Fi, coffee and tea, and all the in-room conveniences that make you feel right at home, even when you’re away.



Power up while you power down. Bedside outlets, a plush duvet, your pick of pillows, and a quiet place to settle in means you’ll get some solid shut-eye.

Green Engage Image

All of our hotels use the IHG Green Engage system, an innovative online environmental sustainability system that gives our hotels the means to measure and manage their impact on the environment. It’s our way of making sure we’re protecting our surroundings for our guests today, and tomorrow.